As a long time IC sufferer I sympathize with your ordeal!!! But I do wonder what "other" conditions in your peovic region your doctors have been looking for? IC is rarely a sole culprit for svere pelvic pain!!!! It is ore the result of years of problems from other diseases like Endometriosis or other autoimmune disorders. Have you ever been checked for Endo? Have they ever done a laperoscopy to really look and "SEE" what is going on inside you? The yeast infections are a result of chronic antibiotics. A probiotic diet would help to control this problem that many of us face. Hope you find some relief soon! PS...The pamphlet that came with my Elmiron says it can take up to 3 months to start working. It also says to follow the instructions carefully, which is VERY difficult to do! Take on an EMPTY stomach 3x a day...NO food 2-3 hours before or after taking the pill. Good Luck!