My husband was diagnosed with WG 2 months ago and has since been on Prednisolone. He is about to start cyclophosphamide (chemo) which really worries me. The side effects sound very bad. I would like to hear from anyone who is having prednisolone and methotreixate instead. Is this less toxic. How long did remission take to occur. My husband seems to have limited WG which has been present in the upper respiratory/sinus. He has responded exceptionally well to treatment of just prednisolone so far. Can anyone help me? I'm worried the treatment will kill him rather than the disease itself.