Hi, I had my gall bladder removed in 1981, so I knew that this was not the problem. The doctors ran a few test, and decided I had acid reflux. But, a further test, with the light down the throat, showed a large Hiatel Hernia. Finally the doctor realized that was the problem all along. And it does affect me more at night. If I eat anything later than 7 P.M. I will suffer for it. What helps me the most beside Pepcid, is plain old Milk of Magnesia taken as an antacid. Good luck, and God bless.