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Almost half of the long term smokers die prematurely because of smoking. Tobacco smoking is the main reason for premature mortality from cancer, chronic obstructive pulmonary disease and cardiovascular disease. It is now found that smoking is also responsible for respiratory tract and other systemic infections. It is known that tuberculosis kills more than twice as many smokers as all forms of cancer combined together. It is also the second largest cause of death from any infectious disease worldwide.