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To those who might be interested. I was dx with pbc in 1990 when I went in for a insurance physical. I have been on Urso since then. I also turned to alternative medicene and take flax seed oil, silymarin (milk thistle, super enzymes and a good vitamin daily. I believe the alternative medicene have helped me alot. I have had one bout of itching and do not have the energy I would like to have. Two years ago I had a esophigal bleed and they had to band two veins in my esophigas. I now go in twice a year for a scope to see if there are any veins that need to be banded. The past 2 years have been a trial as my husband died of a brain tumor and I broke my pelvis and hip. I had to have my hip replaced twice. I have had 16 years with PBC and still feel that I have more. If I can help anyone, please email me.