There are no over-the-counter medications that really help reflux. There are, however, some prescription medications that really help. I take prevacid, which was prescribed by my gastroenerologist. My doctor also told me to use blocks to raise the headboard of my bed by 6". That helps keep the acid down in the stomach where it belongs. Also, don't eat anything after 6:00 p.m., and don't lay down for three hours after eating. I hope this helps you.