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I've been on enderal over 10 years - no help. Can't tolerate mysoline or topamax. Had thaladomy surgery - no help. Very little I can do. It is so embarrassing.Absolutely no social life. Quality of life is nil. I didn't see Janet Reno but she has Parkinsons. I never saw her head shake - only her left arm. Has anyone had trouble with their voice? I'm so bad now that I even have trouble talking.