Every part of my legs from the knees to the toes cramp at night. I've been to several doctors but they have been no help. One prescribed quinine sulfate but I had an allergic reaction to it. I have also tried calcium, multi vitamins, potassium and magnesium. None of those have worked. Some days I go to work with 3 - 4 hours a sleep because of the cramps. Walking seems to work eventually. Some nights I spend more time walking than sleeping. My husband tells me that my legs twitch and move at night. I need some relief from this. It has been going on for years.