Hi Gavin- LDL apheresis is similar to plasmapharesis but it only removes LDL cholesterol and Lp(a) from the blood. HDL cholesterol levels are not reduced. It is a treatment only when diet and medications fail- for some people this is the only option due to their genetic make-up. Treatments are needed every 1 or 2 weeks and each one lasts 2-4 hours. If you want me to send you some more info email me. Good luck!