I have recently learned why I have had pain and stiffness and fatigue. The NSAID Vioxx and dedicated exercise has helped greatly with the pain and stiffness. Does anyone know ways to help with the overwhelming fatigue that accompanies Spondylitis? I am a single mom, age 47, and have a very demanding job which I need to support my family. I also have a mother with Parkinson's disease with related memory loss. I don't know how I can get more rest.