I'm in my forties. Constipated since early childhood. Used every possible laxative and am basically enema dependent. I've been recently trying Perdiem (with Senna)(4 tsp. a.m.) worked great for about four months - now losing effectiveness because building immunity to the Senna stimulant. Anyone have any suggestions, I'd appreciate it. I've been worked up by GI motility expert and completed biofeedback which was somewhat helpful combined with the perdiem. Any advice? thanks.