I was diagnosed with Essential Tremors 12 years ago. It has gotten progressively worse. I have taken Inderal and Mysoline and now the Neurologist has prescribed Topamax. I am anxious to see if it works. Mine is complicated by Anxiety Disorder. I also had the signature stamp made and validated. You do have to modify your life to accommodate this condition, especially if you are right handed and the tremor is in your right hand!! It can be embarrasing when eating in a restaurant, so stick to sandwiches.