be supportive of your sister, get her out and exercise, watch her diet religiously, take her meds, and get her involved with a support group. She is not alone. Many people have Crohn's and live a relatively normal life. My sister has suffered with it for over 40 years and she is a go getter! Write me for her e-mail address. I'm sure she would love to talk to you or your sister. She is a nurse who has the condition and has not let it stop her. She went through the mental thing with it when she was younger also, but there are meds that have helped in that regard also. Don't give up on your sis and don't let her give up on herself.