Dear Kathy. I am the mother of a twenty-five year old son who was diagnosed with AS when he was only 8. We were fortunate to have found a competent doctor who diagnosed him properly the first time out. After moving away 11 years ago we ran into trouble when we were unable to find a doctor with the compassion, understanding, or knowledge to further treat his disability. Severe depression lead to a failed suicide attempt. Both the disability and chronic depression must be properly acknowledged and treated. My son is currently taking MSM/GLUCOSAMINE/CHONDROITIN with great success. He ,overall, complains of no stiffness, pain in his joints, and is able to perform his exercises he has been faithful with since the beginning. While I understand these dietary supplements are not effective for some, I know of many that have had excellent results. You do not have the side effects or risk of damage to vital organs by taking them. The cost of them, for us, is approximately $20.00 a month. Much less than a presciption that may, or may not work. I purchase these dietary supplements from on-line planetrx.com. Be sure to consult with a competent physician before beginning anything new. These dietary supplements may have contraindications with prescribed medications. I wish the best for all.