Yes, I was on depakote and wellbutrin at one time. I was taking 2000 mg of depakote a day. It was too much...I couldn't concentrate or remember things...I was totally wiped out. The wellbutrin gave me tremors so I had to take something else to curb the side effects. Now I'm just on Zoloft and I am doing GREAT! I call it my safety net so that I don't crash. Hope this helps. Good luck!