I have IC as well. The antidepressant that my doctor prescribed me is Elavil. It helps with chronic pain and also (thank God) helps me sleep at night. So I only get up about 2-3 times a night. Someonw mentioned earlier that their doc gave them Elimron, Elavil and Detropan. My doc gave me all that and a pres pain med. The pain is less and so is the urgency - but not gone. Right now I am happy with that.