Hello. I think genetics may play some part in this.I am new to it though and have had some success on the gf/cf diet which also pulls me in that direction. What I do know is that my entire life I would prefer to be alone and insist on to this day having labels facing front and items lined up. If my closet door is cracked at night I can't sleep! (like I get any shut-eye anyway) Two girlfriends of mine with boys on the AS are the same way. So are our moms. Even though I have a very wonderful life I fight daily the urge to just go away and be alone. I felt this way prior to my sons DX. On my mothers side my second cousins have the following with their children- Downs Syndrome Muscular dystrophy A baby born with a heart defect - died of kidney infection a few months after operation. Infertility There's still a few who have'nt had kid yet. Thanks and I hope you find some interest in this.